WASHINGTON (AP) — The United States attacked and seized an Iranian-flagged cargo ship it said had tried to evade its naval blockade near the Strait of Hormuz on Sunday, and Iran’s joint military command vowed to respond, throwing a fragile ceasefire into question days before it expires.

It was the first interception since the U.S. blockade of Iranian ports began last week. Iran’s joint military command called the armed boarding an act of piracy and a ceasefire violation, the state broadcaster said.

With the U.S.-Iran standoff over the strait sharpening and the ceasefire expiring by Wednesday, it was not clear where President Donald Trump ’s earlier announcement on new talks with Iran now stood. He had said U.S. negotiators would head to Pakistan on Monday.

The uncertainty sent oil prices rising again. One of the worst global energy crises in decades threatened to deepen.

Trump on social media said a U.S. Navy guided missile destroyer in the Gulf of Oman warned the Iranian-flagged ship, the Touska, to stop and then “stopped them right in their tracks by blowing a hole in the engineroom.” U.S. Marines had custody of the U.S.-sanctioned vessel and were “seeing what’s on board!”

It was not clear whether anyone was hurt. The U.S. Central Command, which didn’t answer questions, said the destroyer had issued “repeated warnings over a six-hour period.”

Iranian state media suggest new talks won’t take place

There was no comment from Iranian officials directly addressing Trump’s announcement of talks. However, Iranian state media, without citing anyone beyond unnamed sources, issued brief reports suggesting that they would not happen.

Minutes after the ship seizure was announced, Iranian state media reported on President Masoud Pezeshkian’s phone conversation with Pakistan’s prime minister, Shehbaz Sharif, earlier Sunday. U.S. actions, including bullying and unreasonable behavior, have led to increased suspicion that the U.S. will repeat previous patterns and “betray diplomacy,” the reports cited Pezeshkian as saying.

Two previous attempts at talks — last June and earlier this year — were interrupted by Israeli and U.S. attacks.

On another phone call, Iranian Foreign Minister Abbas Araghchi told his Pakistani counterpart, Ishaq Dar, that recent U.S. actions, rhetoric and contradictions were signs of “bad intentions and lack of seriousness in diplomacy,” Iran’s state broadcaster said.

Pakistan did not confirm a second round of talks, but authorities had begun tightening security in Islamabad. A regional official involved in the efforts said mediators were finalizing preparations and U.S. advance security teams were on the ground. The official spoke on condition of anonymity because they weren’t authorized to discuss preparations with the media.

The White House had said Vice President JD Vance, who led the first round of historic face-to-face talks over 21 hours last weekend, would lead the U.S. delegation to Pakistan with envoys Steve Witkoff and Jared Kushner.

Iran on Saturday said it had received new proposals from the United States. While Iran’s chief negotiator, parliament speaker Mohammed Bagher Qalibaf, late Saturday said “there will be no retreat in the field of diplomacy,” he acknowledged a wide gap remained between the sides.

It was unclear whether either side had shifted stances on issues that derailed the last round of negotiations, including Iran’s nuclear enrichment programits regional proxies and the Strait of Hormuz.

Trump’s announcement on talks repeated his threats against Iranian infrastructure that have drawn widespread criticism and warnings of war crimes. If Iran doesn’t agree to the U.S.-proposed deal, “the United States is going to knock out every single Power Plant, and every single Bridge, in Iran,” he wrote.

Iran wants to control strait until ‘war fully ends’

Iran early Monday warned it could keep up the global economic pain as ships remained unable to transit the straitwith hundreds of vessels waiting at each end for clearance.

Security of the strait is not free and “the choice is clear: either a free oil market for all, or the risk of significant costs for everyone,” Mohammad Reza Aref, first vice president of Iran, said in a social media post calling for a lasting end to military and economic pressure on Tehran.

Roughly one-fifth of the world’s oil trade normally passes through the strait, along with critical supplies of fertilizer for the world’s farmersnatural gas and humanitarian supplies for places in dire need like Afghanistan and Sudan.

Iran had announced the strait’s reopening after a 10-day truce between Israel and the Iranian-backed Hezbollah militant group in Lebanon took hold on Friday. But then Trump said the U.S. blockade “will remain in full force” until Tehran reaches a deal with the United States. Iran said it would again enforce restrictions it imposed early in the war. On Saturday, Iran fired at ships trying to transit.

For the Islamic Republicthe strait’s closure is perhaps its most powerful weapon, inflicting political pain on Trump. For the United States, the blockade squeezes Iran’s already weakened economy. Each side has accused the other of violating the ceasefire.

Since most supplies to U.S. military bases in the Gulf region come through the strait, “Iran is determined to maintain oversight and control over traffic through the strait until the war fully ends,” Iran’s Supreme National Security Council said late Saturday. That means Iran-designated routes, payment of fees and issuance of transit certificates.

The council has recently acted as Iran’s de facto top decision-making body.

The war is now in its eighth week after the U.S. and Israel launched it on Feb. 28 during talks over Tehran’s nuclear program. A t least 3,000 people have been killed in Iran, more than 2,290 in Lebanon23 in Israel and more than a dozen in Gulf Arab states. Fifteen Israeli soldiers in Lebanon and 13 U.S. service members throughout the region have been killed.

___ Magy reported from Cairo and Metz from Ramallah, West Bank. Associated Press writer Munir Ahmed in Islamabad contributed to this report.

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An earlier version of this story corrected the name of the Iranian foreign ministry spokesperson to Esmail Baghaei.

HAVANA (AP) — Havana’s broad avenues are empty at night. Theaters are closed. Bars and cafes have curtains lowered. It’s hard to find lights in the streets or Cubans making money entertaining tourists.

Under the weight of an oil embargo imposed by the second administration of U.S. President Donald Trump, and the island’s most severe economic crisis in decades, the city’s once bustling nightlife has gone quiet.

“I feel empty inside when I see my streets empty,” said Yusleydi Blanco, a 41-year-old accountant. “I can’t be happy when my country is sad.”

‘Worse than the Special Period’

Following a 2016 deal between then-Presidents Barack Obama and Raúl Castro easing U.S. travel restrictions on Cuba, money flooded the island as tourism spiked. A small number of entrepreneurs opened newly allowed private businesses and bought imported modern vehicles that shared the streets with classic cars from the 1950s.

In 2018, a record 4.7 million tourists arrived on the island. Hotel accommodations were so saturated that travelers without lodging were seen sleeping in a park in the small western Cuban town of Viñales that draws thousands of tourists and rock climbers to its scenic limestone cliffs.

Today, gasoline sales are limited to 20 liters (5 gallons) per vehicle and owners can wait months for a turn at the pump. Buses now stop running at 6 p.m. and international airlines including Air France, Air Canada and Iberia have stopped flying to Havana because they can’t refuel there. The sound of cars has disappeared in the wealthy El Vedado neighborhood, where the soundscape of chirping birds has reemerged.

The Cuban government reported the arrival of 77,600 tourists in February, down from 178,000 on the same month a year ago.

“This is worse than the Special Period,” said 65-year-old parking attendant Dolores de la Caridad Méndez about the years of economic devastation that followed the collapse of the Soviet Union, Cuba’s Cold War patron, in the 1990s.

‘Testing everyone’s stamina’

In contrast with his Democratic predecessors, U.S. President Donald Trump has tightened economic sanctions against Cuba, demanding an end to political repression, a release of political prisoners and a liberalization of the island’s ailing economy.

The deepening crisis has led to persistent blackoutscuts to the state-run food ration system, and severe shortages of water and medicine that have transformed daily life into an ordeal for many in the island of 10 million. Between 2021 and 2024, approximately 1.4 million Cubans left the island — mostly young people but also accomplished musicians, actors, dancers and other entertainers who fueled Havana’s nightlife.

In January, the U.S. captured then-President Nicolás Maduro of Venezuela, which had been Cuba’s primary supplier of oil. The Trump administration severed that supply and threatened to impose tariffs on other countries that sold oil to Cuba, which went without a single shipment until a Russian tanker came in March.

For entrepreneurs and business owners across the island, life has become difficult as tourism plummeted and their hopes of selling cheaper goods to fellow Cubans dashed against the rocks of a vastly harder economic reality.

“You wake up and you’re ready to conquer the world, saying, ‘Today I’ll sell more than ever,’” said Yeni Pérez, owner of the Old Havana cafe Entre Nos. “Then not a single client comes in and you go home devastated.”

“The next day,” she said, “You say, ‘Let’s give it another chance.’ It’s a time that’s testing everyone’s stamina.”

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WASHINGTON (AP) — President Donald Trump on Saturday directed his administration to speed up reviews of certain psychedelic drugs, including ibogaine, which recently has been embraced by combat veterans and conservative lawmakers despite having serious safety risks.

Ibogaine and other psychedelics remain banned under the federal government’s most restrictive category for illegal, high-risk drugs. But the administration is taking steps to ease restrictions and spur research on using the drugs for medical purposes, including conditions like severe depression.

“Today’s order will ensure that people suffering from debilitating symptoms might finally have a chance to reclaim their lives and lead a happier life,” Trump said as he signed an executive order on the drugs. The Republican president said his directive will help “dramatically accelerate” access to potential treatments. “If these turn out to be as good as people are saying, it’s going to have a tremendous impact,” he said.

Veteran organizations and psychedelic advocates have long contended that ibogaine, which is made from a shrub native to West Africa, has great promise for hard-to-treat conditions such as post-traumatic stress disorder and opioid addiction.

Trump’s announcement follows pledges by Health Secretary Robert F. Kennedy Jr. and other administration officials to ease access to psychedelics for medical use, an issue that has won rare bipartisan support.

Joining Trump in the Oval Office were his top health officials, conservative podcaster Joe Rogan and Marcus Luttrell, the former Navy SEAL whose memoir about a deadly mission in Afghanistan was the basis of the film “Lone Survivor.” Rogan said he texted Trump information on ibogaine and the president responded: “Sounds great. Do you want FDA approval? Let’s do it.”

“You’re going to save a lot of lives through it,” Luttrell told Trump during the ceremony. “It absolutely changed my life for the better.”

The Food and Drug Administration next week will issue national priority vouchers for three psychedelics, which the agency’s commissioner, Marty Makary, said will allow certain drugs to be approved quickly “if they are in line with our national priorities.” The vouchers can cut review times from several months to a period of weeks. It is the first time the FDA has offered that fast-tracking to any psychedelics.

The FDA is also taking steps to clear the way for the first-ever human trials of ibogaine in the U.S.

Trump’s action surprised many longtime advocates and researchers in the psychedelic fieldgiven that ibogaine is known to sometimes trigger potentially fatal heart problems. The National Institutes of Health briefly funded research on the drug in the 1990s, but discontinued the work due to ibogaine’s “cardiovascular toxicity.”

“It’s been incredibly difficult to study ibogaine in the U.S. because of its known cardiotoxicity,” said Frederick Barrett, director of the Johns Hopkins Center for Psychedelic and Consciousness Research. “If the executive order can pave the way for doing objective, scientific research with this compound, it would help us understand whether it is truly a better psychedelic therapy than others.”

No psychedelic has been approved in the United States, but a number of them are being studied in large trials for various mental health conditions, including psilocybin, MDMA and LSD. All those drugs remain illegal, classified as Schedule I substances alongside drugs such as heroin. Two states — Oregon and Colorado — have legalized psychedelic therapy with psilocybin.

Ibogaine was first used by members of the Bwiti religion in African nations like Gabon during their religious ceremonies.

In recent years, U.S. veterans have reported benefiting from the drug after traveling to clinics in Mexico that administer it.

Backing from veterans groups and former Texas Gov. Rick Perry led to a law last year providing $50 million for ibogaine research in that state. Perry, who co-founded a group called Americans for Ibogaine, recently appeared on Rogan’s podcast, making the case for reducing federal limits on the drug. It was his second time talking about ibogaine on the popular podcast in the past two years.

Trump’s order calls on the Department of Health and Human Services to direct at least $50 million to states that have enacted or are developing programs to advance psychedelic drugs for serious mental illness. It’s described as a federal-state partnership to provide funding, technical assistance and data sharing.

Ibogaine is known to cause irregular heart rhythms and has been linked to more than 30 deaths in the medical literature, according to the Multidisciplinary Association for Psychedelic Studies, a nonprofit that conducted some early studies in patients outside the U.S.

The group’s co-executive director, Ismail Lourido Ali, said Trump’s order might encourage other states to follow the Texas model.

“The stigma around Schedule I drugs is significant,” Ali said. “It feels like this would give pretty substantial cover for Republican governors and legislatures to step into the ring in terms of funding research programs at their universities.”

Owners of ibogaine clinics said the impact of the order will not be immediate.

“There will be no insurance coverage, it will still be considered unapproved and non-covered care,” said Tom Feegel of Beond Ibogaine, which operates a clinic in Cancun, Mexico. “But what it does mean is that ibogaine shifts from being fringe and underground to being federally acknowledged.”

Feegel says his clinic treated 2,000 people with ibogaine last year for between $15,000 and $20,000 per person. The company also gave free treatment to about 100 veterans.

Clinics that use the drug typically monitor patients’ heart readings and have emergency medical equipment on hand.

One of the only recent studies conducted by U.S. researchers found that veterans treated with ibogaine showed improvements in symptoms of traumatic brain injury, including PTSD, depression and anxiety. The Stanford University study was small — enrolling 30 veterans who received the drug in Mexico. It did not include a placebo group for comparison, an essential feature of rigorous medical research. Patients in the study received a combination of ibogaine mixed with magnesium intended to reduce heart risks.

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The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.