President Donald Trump keeps knocking out his political enemies in the GOP. On Saturday, Sen. Bill Cassidy was the latest to fall.

It’s a massive warning sign for any Republicans who’ve provoked the president’s wrath: Trump’s revenge campaign has already mobilized voters in both Indiana, where he successfully ousted several state GOP senators over redistricting, and Saturday night in Louisiana. Tuesday’s primaries in Georgia and Kentucky, where Rep. Thomas Massie is up for reelection and he’s picked sides in the open Senate race, will be another test. Now, the president is entering those races with the wind at his back. 

Cassidy’s distant third-place finish marks the end of his tenure in the Senate, one that was doomed by his vote to convict Trump on impeachment charges related to the Jan. 6 insurrection five years ago.

That decision ostracized him from Louisiana’s rabidly conservative base and set up two strong primary challengers in Rep. Julia Letlow — the Trump-endorsed candidate — and MAGA-friendly state Treasurer John Fleming. Up until polls closed, Cassidy maintained that his massive war chest, his record in Congress and a high turnout of non-party voters would be enough to save him.

In the end, it was not.

“For a man with such a formidable intellect, his political strategy was breathtakingly dense,” said Lionel Rainey, a Louisiana GOP strategist, who is unaffiliated with any of the campaigns. “History will remember Bill Cassidy as the absolute smartest guy in the political morgue.”

Letlow, boosted by Trump’s support, advanced to a runoff with a significant lead over Fleming — evidence that his endorsement is still key for Republican voters and can boost a candidate who begins a race with relatively low name ID and fundraising power.

Trump on Saturday night declared online that Cassidy’s “disloyalty to the man who got him elected is now a part of legend, and it’s nice to see that his political career is OVER!”

As Cassidy took the stage in Baton Rouge to concede and thank his supporters, he appeared to repeatedly needle Trump in his remarks, possibly previewing a potentially adversarial role to the White House he will take on as a lame duck senator.

“Insults only bother me if they come from somebody of character and integrity, I find that people of character and integrity don’t spend their time attacking people on the internet,” he said at one point, after taking apparent digs at Trump for refusing to accept his 2020 loss was legitimate and declaring that “leaders should think through the consequences of their actions.”

Cassidy’s suddenly pointed criticism of the president following his loss suggests he could quickly turn into a headache for the White House. He has already blocked a handful of White House appointees, and still chairs the powerful Senate Health, Education, Labor and Pensions (HELP) Committee. Without the need to woo the president, he could follow the path of retiring Sen. Thom Tillis (R-N.C.) and refuse to fall in line on some key votes — an important factor in a fairly narrowly divided Senate.

Throughout the campaign, Cassidy tried to cast Letlow as insufficiently conservative, nicknaming her “Liberal Letlow” and hammering her for her past support of diversity initiatives in higher education. But those attacks did not stick.

Trump didn’t dip into his own MAGA Inc. coffers or appear on the campaign trail to elevate Letlow — but she still benefited from some of his allies. The Make America Healthy Again PAC pledged $1 million in support of her candidacy, angered by Cassidy’s skepticism of Robert F. Kennedy Jr. becoming the Health and Human Services secretary. Those frustrations grew when the senator blocked Casey Means’ nomination as U.S. Surgeon General, which the White House later pulled.

Cassidy’s attempt at self-preservation was also stymied by the rise of Fleming, a former Freedom Caucus member who claimed he was the most conservative candidate in the race. In the final hours, Fleming got a shoutout from Trump as well, who posted earlier Saturday that Cassidy must be “CLOBBERED” by “two great people!!!”.

Letlow’s first-place finish is a boon for Louisiana Gov. Jeff Landry, who aggressively campaigned for her with his endorsement, pressured big donors to get in line behind her and was behind Louisiana closing its primary system — a move that disadvantaged Cassidy, who has historically brought in some Democratic voters.

The runoff, scheduled for late June, sets up a new battle for the president’s base: Do they go with the Trump-chosen option in Letlow or the other MAGA candidate in Fleming, who previously worked as White House aide under Trump? Pre-runoff polls showed a close race between the two, though Letlow comfortably led Fleming in the first round. The extended primary is sure to be bruising.

As the polls closed on Saturday evening, Trump had already begun to expand his target map, singling out Rep. Lauren Boebert (R-Colo.) for campaigning on behalf of Massie, who is facing his own tough reelection fight in Kentucky against Trump-backed primary challenger Ed Gallrein. (Colorado’s filing deadline has already closed, so it’s unlikely that threat can be carried out this election.)

“Is anyone interested in running against Weak Minded Lauren Boebert in Colorado’s Fourth Congressional District?” he wrote on Truth Social. “Even though I long ago endorsed Boebert, if the right person came along, it would be my Honor to withdraw that Endorsement, and endorse a good and proper alternative.”

Sen. Bill Cassidy (R-La.) just lost his seat — a key victory for President Donald Trump’s revenge tour this cycle.

Rep. Julia Letlow, the Trump-backed candidate, and state Treasurer John Fleming advanced to a runoff in the Louisiana GOP Senate primary on Saturday, with Cassidy finishing in third place.

It’s a remarkable result: Cassidy is the first senator of either party to lose in a primary since 2012. The two-term senator and chair of the powerful Senate Health, Education, Labor, and Pensions (HELP) Committee failed to even make the runoff, finishing with roughly a quarter of the vote.

Both Letlow and Fleming benefited from MAGA voters’ frustrations with Cassidy for his 2021 vote to convict Trump on impeachment charges related to the Jan. 6 insurrection, and for his skepticism of Trump’s decision to nominate Robert F. Kennedy Jr. as Health and Human Services secretary.

The president, who has been itching to oust Cassidy, finally got his wish Saturday. The result follows Trump’s successful attempts to oust several GOP state senators in Indiana last month over redistricting clashes.

Letlow, a three-term representative from north Louisiana, jumped into the race with Trump’s endorsement, a huge boost in the deep-red state. Gov. Jeff Landry also endorsed her and worked behind the scenes to help her campaign, and the Make America Healthy Again PAC committed $1 million to supporting her.

Fleming, a former member of Congress and White House aide under Trump, drew deep grassroots support during his campaign and was able to cut into Letlow’s polling lead in the final days of the race.

The runoff will extend an already expensive battle for the GOP nomination to late June. Early polls suggest a tight race between Letlow and Fleming, though Letlow had a clear advantage in the first round of voting.